Endocrine Abstracts

Introduction: Lymphocytic hypophysitis is a strange cause of hypopituitarism which can represent a difficult diagnostic and therapeutic challenge.Objectives and methods: Describe the diagnosis, evolution and treatment of a case of lymphocytic hypophysitis in a patient who began with hypopituitarism and a year after the diagnosis had local symptoms. We reviewed the medical history of the patient from the moment the patient contacted with us to the months ...

Introduction and objectives: The inhalation of tobacco smoke leads to an acute increase in cortisol, ACTH and GH concentration, both in chronic smokers as in non-smokers. However, most studies have failed to demonstrate differences between both groups in basal levels of these hormones in plasma or urine. Additionally, cholinergic pathways have been shown to play an inhibitory role in ACTH secretion in non-smokers. UFC and circulating levels of cortisol, ACTH and GH were evalua...

Introductions: Alterations of the somatotrophic and hypothalamic–pituitary–adrenal (HPA) axes occur frequently in patients with poorly controlled DM-1. These disorders could be related to abnormalities in the cholinergic tone regulating both hormonal axes.Subjects and Methods: UFC (urinary free cortisol) on 24 h urine samples and the effects of placebo and pyridostigmine on ACTH, cortisol, GH and glucose circulating levels were studied in 16 yo...

Introduction and Objectives: In patients with poorly controlled DM-1, the frequently observed alterations of somatotrophic axis seem to be related to abnormalities in the hypothalamic cholinergic tone regulating this axis. The effects of cholinergic stimulation on GH responses to GHRH were evaluated in patients with poorly controlled DM-1 and the relationship of these responses to metabolic control and kidney function tests.Subjects and Methods: Microalb...

The diabetogenic risk associated with statin therapy is higher in patients with pre-existing risk factors, such as metabolic syndrome (MS).Objective: To assess changes in lipid and glycemic profile in dyslipidemic subjects with MS after statin therapy.Methods: Observational, retrospective, multi-center study, conducted in 40 endocrinology Spanish hospitals. Each endocrinologist included the first 10 patients >18 years with MS, ...

Our objective was to estimate the distribution of Spanish diabetic patients attending to individualized glycaemic targets recommended by the ADA/EASD consensus with and without considering hypoglycaemia risk. We conducted a cross-sectional study in a Spanish primary care setting between 2011 and 2012. A total of 5382 type 2 diabetic subjects under antihyperglycaemic treatment for at least 3 months prior to inclusion completed a study visit in which clinical data including age,...

Background: Thorough history taking and clinical examination is vital in the assessment of all medical patients. However, diagnosis of endocrine disease also relies on appropriate biochemical tests. Previously in our unit, tests were only performed after new patients attended clinic. We proposed that diagnosis and management would be improved if this system was inverted.Method: In 2009 clinicians, nurses and chemical pathology representatives reviewed av...

Introduction: Symptomatic hypogonadism affects 5–6% of men aged 30–79 years and is associated with increased morbidity and mortality. There are currently no trust guidelines for the diagnostic workup of these patients.Methods: Retrospective analysis was performed of diagnosis and assessment of adult men with low serum total testosterone (TT) and compared with clinical practice guidelines of The Endocrine Society. We identified all patients with...

Introduction: The incidence of end stage renal failure (ESRF) secondary to diabetes mellitus (DM) is increasing worldwide. Renal replacement therapy, which if started early improves prognosis, is a common treatment for ESRF.Objective: To determine the waiting time and factors that influence the provision of emergency renal replacement therapy in patients with ESRF secondary to DM admitted to the emergency room of a tertiary care hospital.<p class="ab...

The development and maturation of kisspeptin neurons is critical for activating GnRH release needed to initiate puberty. However, little is known of the development and organization of kisspeptin neurons in the human hypothalamus and the anatomical architecture of kisspeptin neurons in rodents is distinct from that of primates.The aim of the present study was to examine the development of the hypothalamic neuroendocrine circuitry that sets the structural...